I keep coming back to the use of two Holley 2Vs? I have never seen this setup, but it could look great with a custom oval 427 style air cleaner. I agree it's not vintage 50s hot rod, but to an old FE guy it looks great.
Drive ability should be responsive. You wouldn't need complicated progressive linkage and the carbs are readily available. Would turn some heads on cruise nights and start a lot of conversations. If you used two center pivot Holley 2Vs, you could call it a 4 pack! (no bumble bee stripes please)
Obviously you would need to use adapter plates. Would the 2V carbs and adapters distribute fuel correctly to the 4V holes in the manifold? Would any modifications be needed to an Edelbrock 257?