In general using a larger carb than necessary will reduce the responsiveness of the engine and could present other tuning difficulties. That said, you do want to err on a vacuum secondary carb being a little bigger than needed. Key words are "a little."
If you are nearly certain that you will build a modified motor, get the 600. I suggest the Street Avenger series, which would be 570, because it is a more modern carb and you get some good features for the money. If an engine build is something that you are merely tossing around as an idea, get the 450 as it will be more than needed for your motor. Another thing to consider is depending on your future engine build, the 600 may actually be too small. That's just another reason that it is best to pick a carb for what you have now rather than what you think you might have in the future.
You should also consider the Summit Racing branded carburetors which are available in 500, 600, and 750cfm sizes. You get a lot for the money with those carbs.
Lawrenceville, GA